The freeze drier made by our company is designed and manufactured strictly according to
GMP Specifications, and has the following merits:
All the parts contacting the products are made of ALSL 316L stainless steel, the surface
roughness reaches R a≤0.5u m.
The inner circle of the chest has a smooth transition without dead corner, no objects accumulated.
Consider for user, the structure is easy to clean.
Option for steam sterilization or chemical sterilization.
Except for the above, our company can also provide automatic running CIP(on-site cleaning)
and SIP(steam sterilization) functions to ensure the high quality of cleaning and the
sterilization of the equipment.
Use overheats pure steam (121ºC).
Equipped with cooling water jacket, after sterilizing, it can fast reduce the temperature of
the chest (if less than 20, the equipment is CZPT configuration.)
Optional pneumatic door lock, it locks automatically.
Use import sterilization filter to ensure the absolutely sterilized air coming into equipment.
The chest and various kinds of container and tube are all wrapped with import insulating
layer to efficiently avoid from heat transmission.
Can carry out constant humidity control to the refrigeration humidity.
Equipped with water circulation pump capable to eliminate residual water in sterilization
The high pressure clean water thoroughly wash inner surface of the chest and condenser.
Equipped with large flow rate CIP pump.
Fixed with CIP tubing that automatically drains the residual water.
Use rotary fixed nozzle with 360-degree spray.
The hydraulic system uses isolated retractable corrugated tube.
The freeze drier made by our company has a proper layout and enough space to benefit
the maintenance and operation of the equipment.
Square or round shape chest(use may choose one of them)
Horizontal of vertical condenser
Integral design can fully use space.
Separate design can make each component independent, easy to operate and maintain.
Working temperature scope of condenser: -8ºC( when it is dry)~+121ºC(when in steam sterilizing).
Pressure scope of the chest:1Pa
Use industrial pressure container CZPT: GB150-1998 series.
Conform to national vacuum equipment CZPT: GB/T3163-3164
GMP and FDA relevant regulations.
Standard of international CZPTtrotechnical Commission(IEC)
¬ China CZPTtric CZPT Standard(GB)
¬ The chest, lamellar and condenser is make of AISI316L stainless steel.
¬ TIG welding avoids gap that can not be cleaned and possible leakage.
¬ The welding point the tube is photographed with X-ray, with inspection record and certification of qualification.
¬ The roughness of inner surface reaches R a≤0.5u, mirror polished.
¬ Leakage rate of the system≤ 5*10(-2) mbar 1/s to ensure normal and reliable running.
¬ There is no dead corner in the chest, the connection of tube is simple and reasonable, easy to clean.
The vacuum system of the freeze drier providers a necessary pressure environment to freeze drying procedure. Cooperating with condenser, it can reach the vacuum leaver required by the freeze drying procedure. To make the system run stably under high vacuum
scenario. The key point is the performance of the vacuum pump, and the valve, seal and
instrument that cooperate with the pump.
The vacuum system of our freeze drier has the following characteristic:
Standard configuration, uses Edwards double stage oil sealing revolving plate pump.
Choice: Edwards pump
Equipped with two vacuum probes, for measuring the vacuum level of freeze drying chest
and pump resectively.
Alternative: condenser type vacuum meter.
There are two methods for drying chest vacuum level control:
one. Drying chest vacuum level controls the opening and closing of the air inlet valve,
introduce the sterilized air from sterilized room.
two. Drying chest vacuum level controls the opening degree of the big butterfly valve to reach the purpose of controlling the vacuum level.
The drying chest and water capture valve, circulating pump, spotlight and etc. of the freeze drier, like other components of the freeze drier, use the first class components from other countries or from domestic factories.
The above systems of our freeze drier have the following characteristics:
A coupleclamping butterfly valve is equipped between the drying chest and water capture
to keep a no leakage seal in both directions.
Use labial margin seal design to compensate the change of temperature and pressure during operation.
Eccentric valve rod and eccentric butterfly valve eliminate the wear-out of upper and lower ends of valve seat during frequent opening.
May choose electric of pneumatic driving device.
CZPT CZPT electric driver can stepless adjust the opening wideness of butterfly valve, control the vacuum level of the drying chest to avoid from being polluted.
CZPT steel valve body and TEF elastic valve seat conform with GMP specification.
The drying chest and water capturer are equipped with viewing glass. The viewing glass can be equipped with spotlight to obtain clear procedure monitoring.
Shelf refrigerating heating system uses Denmark Grundfos UPS circulation pump, Sweden plate type heat exchanger, The size of the exchanger is small, this reduces the heat conduction mediator and energy consumption, raises the refrigeration efficiency.
The control system of the freeze drier provides a reliable whole procedure control for the freeze drier. It has advanced functions of display, control, recording, printing and alarming.
The control system of our freeze drier has the following characteristics:
The mains air switch, transformer and AC contactor fixed in electric cabinet are Siemens
goods. The electric cabinet is secured on machine frame. All machine pump motors are
equipped with overheat protection, solenoid valve and heating circuit are equipped with
The display screen uses Mitsubishi touch screen, PLC programmable logic controller,
indicating light, sound-light alarming system, and etc.
Temperature measuring, pressure measuring, the components can work normally under
high temperature, ultra-low temperature and high vacuum level with high reliability.
The control system can display the running status of all components of the whole system,
and can store and process the operation information and various data. It can provide
procedure recording report of whole freeze drying process. It can alarm on failure or
abnormal situation, provide checking for maintenance, the operator can set and modify
data and steps.
Our company operates it’s own internal CZPT Management system that provides the
foundation for ISO 9001 accreditation. This system provides the basis for comprehensive
documentation of the manufacture of all its products, ensuring customers are provided with full details of their equipment.
Standard documentation supplied with every freeze dryer includes:
¬ electrical diagram
¬ P&L diagram
¬ Component list
¬ Certificates of conformance for
¬ Critical components
¬ Operating instructions
¬ Maintenance instructions
¬ Copies of pressure vessel certificates
Our company also able to provide IQ and OQ documentation to assist customers with equipment validation. Calibration documentation is also available. These services are not part of the CZPT scope of supply.
|Lamel lay area()||.five||1||two||3||6||eight||ten||fifteen||twenty||30||forty||fifty|
|Lamel lay size(mm)||three hundred*
|Number of lamel lay||4+1||four+1||4+one||four+1||five+1||7+one||seven+1||eight+1||10+1||10+one||sixteen+two||twenty+two|
|Lamel lay spacing(mm)||eighty||a hundred|
|Lamel lay smoothness(mm/m)||±0.1||±0.2|
|Lamel lay surface roughness(Ra)||.8|
|Lamel lay lowest temperature(ºC)||-50~-60||-50~-sixty||-fifty~ -fifty~-sixty||-fifty~-60||-50~-60||-fifty~-60||-50~-60||-fifty~-sixty||-fifty~-60||-50~-60||-fifty~-sixty||-50~-60|
|Lamel lay temperature scope (ºC)||-sixty/+121|
|Shape of chest||Cylinder||Rectangular|
|Chest inner surface polish||Mirror|
|Structure and shape of water capturer||Horizontal cylinder||Horizontal vertical cylinder||Horizontal cylinder|
|Lowest temperature of water capturer(ºC)||-80||-80||-eighty|
|Capturing amount of water capturer(kg)||7.five||fifteen||thirty||forty five||90||one hundred twenty||150||225||three hundred||450||600||750|
|Vacuum suction rate(m3/h )||eighteen||30||40||60||eighty||one hundred twenty||a hundred and sixty||240||350||525||seven hundred||825|
|Control system||CZPT + manual|
|Power of whole machine(kw)||5||seven.5||twelve||20||forty||50||55||75||a hundred||a hundred twenty five||one hundred eighty||220|
|CZPT water amount(T/H)||CZPT by air||2||four||4||eight||twelve||12||20||24||36||48||48|
|CZPT plug(alternative) CZPT plug
separation corrugated tube(choice)
|Diagram recording instrument||√|
|Weight of whole machine(kg)||2000||3000||3500||5000||6500||7500||9000||12500||13800||17800||22800||26000|
|External size(L*W*H (m) )||1500*
The freeze drier made by our company is designed and manufactured strictly according to GMP Specifications.